RESPONSE

RESPONSE (REsting and Stimulus-based Paradigms to detect Organized NetworkS and predict Emergence of consciousness) is an MRI and EEG study of brain network structure and function in patients with acute severe traumatic brain injury. The primary goal of this study is to determine if acute MRI and EEG predict long-term outcomes. A secondary goal of this study is to identify longitudinal changes within brain networks that support recovery of consciousness, communication, and functional independence.

The above figure shows task-based functional MRI (fMRI) and EEG techniques being used by NICC researchers to identify brain activity in patients with acute severe traumatic brain injury. Figure adapted from Edlow, Chatelle et al. Brain 2017. — The above figure shows task-based functional MRI (fMRI) and EEG techniques being used by NICC researchers to identify brain activity in patients with acute severe traumatic brain injury. Figure adapted from Edlow, Chatelle et al. *Brain* 2017.

Selected RESPONSE Publications

Edlow BL*, Chatelle C*, Spencer CA, Chu CJ, Bodien YG, O’Connor KL, Hirschberg RE, Hochberg LR, Giacino JT, Rosenthal ES**, Wu O**. Early detection of consciousness in patients with acute severe traumatic brain injury. Brain. 2017;140:2399-2414. (*co-first authors, **co-senior authors) PMCID PMC6059097. [PubMed] [Altmetric] [Editorial]

Threlkeld ZD, Bodien YG, Rosenthal ES, Giacino JT, Nieto-Castanon A, Wu O, Whitfield-Gabrieli S, Edlow BL. Functional networks reemerge during recovery of consciousness after acute severe traumatic brain injury. Cortex. 2018;106:299-308. PMCID PMC6120794. [PubMed] [PlumX]

Snider SB, Bodien YG, Bianciardi M, Brown EN, Wu O, Edlow BL. Disruption of the ascending arousal network in acute traumatic disorders of consciousness. Neurology. 2019;93:e1281-e1287. PMCID pending. [PubMed] [Altmetric] [GitHub]

Bodien YG*, Threlkeld ZD*, Edlow BL. Default mode network dynamics in covert consciousness. Cortex. 2019; doi: 10.1016/j.cortex.2019.01.014. [Epub ahead of print] (*co-first authors) PMC6527357. [PubMed] [PlumX]

Edlow BL, Fins JJ. Assessment of covert consciousness in the intensive care unit: Clinical and ethical considerations. Journal of Head Trauma Rehabilitation. 2018;33:424-434. PMCID PMC6317885. [PubMed] [Altmetric]

Edlow BL. Covert consciousness: Searching for volitional brain activity in the unresponsive. Current Biology. 2018;23:R1345-R1348. [PubMed] [PlumX]

Chatelle C*, Rosenthal ES*, Bodien YG, Spencer CA, Giacino JT**, Edlow BL**. EEG correlates of language function in traumatic disorders of consciousness. Neurocritical Care. 2020; doi: 10.1007/s12028-019-00904-3. [Epub ahead of print]. (*co-first; **co-last) PMCID pending. [PubMed] [Altmetric]